Structure-depending measures tends to make access to a protein–DNA interaction opportunity mode and offered protein–DNA amazingly structure to evaluate the newest joining attraction of a particular TF and you may a joining attraction value that’s lower than certain tolerance would suggest a potential binding website [ eleven ]
Our build-built anticipate did not functions very well on eukaryotic TFBS compared that have sequence-created methods. Possibly the primary reason is the less than-testing regarding contact regarding the framework database. We remember that during the eukaryotic TFBS anticipate, the fresh new sequence-created means have a much larger take to proportions than just one to during the prokaryotic instance. Therefore, the favorable results out-of sequence-established method is requested because they do have more information about the fresh binding web site.